ATGC Bioinformatics

Analysis pipeline

DNA methylation array analysis

Reproducible EPIC and 450K array analysis from IDAT quality control to differential methylation and biological interpretation.

Workflow

Six stages, one traceable analysis

  1. 01

    Sample sheet, phenotype, array type, and study-design review

  2. 02

    IDAT import, probe-level quality control, and sample diagnostics

  3. 03

    Background correction, normalization, and problematic-probe filtering

  4. 04

    Cell-composition, batch, and technical-confounder assessment

  5. 05

    Differentially methylated position and region analysis with annotation

  6. 06

    Pathway results, visualizations, methods, and analysis-ready handoff

Built around the experiment—not a black box.

Tools and parameters are selected after reviewing study design, sample size, data quality, biological replicates, and the intended use of the results. Deliverables include methods documentation and analysis-ready outputs.

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